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Notably, one of the main areas of drug discovery and the treatment of inflammatory diseases is the optimization of low molecular weight medications

[38, 39, 40, 41] This approach produces neutralizing antibodies (nAbs) against these proinflammatory biomolecules to inhibit their activities

10.1038/s41389-021-00309-y 19 DiW.KhanM.RasulA.SunM.SuiY.ZhongL.et al (2014)

The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is a 79-kDa key bifunctional enzyme of sialic acid biosynthesis that consists of N-terminal epimerase and C-terminal kinase domains 2

It flips off one wasteful switch and lets the cell hold onto resources it was throwing away

Peak plasma concentrations after standard oral doses are in the low nanomolar range (typically 550 nM), far below the micromolar concentrations (150 M) used in most in vitro studies (165, 166)