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Continuous positive airway pressure can improve depression in patients with obstructive sleep apnoea syndrome: a meta-analysis based on randomized controlled trials

Signs include feeling heavy or tired, dry mouth, irritability, or feeling "toxic" or not quite right

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Particularly promising are agents that integrate complementary mechanisms, simultaneously mitigating neuroinflammation, counteracting oxidative stress, and preserving synaptic integrity, to address the diseases multifactorial nature [33, 34]

Any animal-model protocol should include defined humane endpoints, veterinary oversight, and IACUC or equivalent ethics-committee approval before initiation

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