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For instance, siBec1@PPN nanoparticles deliver siRNA against Beclin-1 to silence autophagy, reverse treatment resistance, and potentiate combined anticancer therapies [71]

doi: 10.1182/blood-2011-04-348540 75 PorterDLHwangWTFreyNVLaceySFShawPALorenAWet al

In vivo studies confirmed the ability of functionalized AuNPs and AuNRs to cross the BBB as both formulations were found in the brain of mice in larger quantity than the bare formulations