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The mechanism underscoring this link remains elusive

Many relevant studies have shown that inhibition of enzymes like ChE, secretase family, and prolyl endopeptidase can be considered first-step assays for determining the neuroprotective effects against AD since the currently available clinical drugs against AD are mostly ChE inhibitors

doi: 10.1016/j.humimm.2021.09.004 62 RoeKGibotSVermaS

Tasdogan, A

Hypoxia induces the UPR through activation of the ER stress sensor molecules activating transcription factor 6, inositol-requiring protein 1 (IRE1), and PKR-like ER kinase (PERK) (1 in Fig