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"Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer." Nature Reviews Drug Discovery, 6(10), 821-833

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Conclusion: Hence the subclinical hypothyroidism, prevalent in overweight individuals aged 46-60 particularly in female is very high compare to overt hypothyroidism, where TSH was positively correlated with the Glutathione peroxidase (GPx) and Malondialdehyde (MDA), representing increased TSH levels are associated with increased oxidative stress in body