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Caspases can serve different roles in the apoptotic cascade: some act as initiators (e.g., caspase-8, caspase-9), while others function as effectors (e.g., caspase-3, -6, -7), ultimately executing apoptosis by cleaving essential cellular proteins [159]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Qvist P., Bay-Jensen A.C., Christiansen C., Dam E.B., Pastoureau P., Karsdal M.A

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SARS-CoV-2 infection requires a high basal energy expenditure for immune activation, hyper-inflammation (cytokine storm), anorexia followed by muscle loss, weakness, and fatigue 643