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P., Holm, S., Maroudas, A

Saukkonen T, Shojaee-Moradie F, Williams RM, Amin R, Yuen KC, Watts A, Acerini CL, Umpleby AM, Dunger DB

Notably, pharmacological inhibition of either AMPK or autophagy partially restores cell viability but fails to rescue ATP levels, suggesting that hyperactivated mitophagy consumes residual functional mitochondria, thus perpetuating a deleterious feedback loop 32

AKCEA-APO(a)-LRx Study Investigators

Contributing factors for T1D pathogenesis, includes genetic factors (HLA, Insulin-VNTR, CTLA-4, PTPN22, AIRE, FoxP3, STAT3, IFIH1, HIP14, ERBB3), epigenetic factors, environmental factors (viruses like rubella and enteroviruses), diet (cereals, cows milk, vitamin-D, and omega-3 fatty acids), gut microbiota, and immunologic factors (Paschou et al., 2018)