glutathione alkylating agents Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Oncology

Glossary GLP-1 (Glucagon-Like Peptide-1) An incretin hormone produced in the gut that suppresses appetite, slows gastric emptying, and promotes insulin secretion

Keywords Bretylium Trade Name: generic Drug Class: Antiarrhythmic Mechanism of Action: (after an initial phase of causing the release of catecholamines) Interferes with the neuronal release of catecholamines Bretylium also lengthens the duration and effective refractory period in heart tissue (a Class III effect), an effect that is most pronounced in ischemic cells (which have shortened action potential durations) Indications: No longer available in the United States Previously used for attempted resuscitation from ventricular fibrillation after lidocaine and cardioversion have failed Side Effects: Precipitation of cardiac arrhythmias at the onset of drug therapy due to its ability to cause the initial release of catecholamines (when used as an antiarrhythmic)

In summary, NAC transiently improved tissue oxygenation in about half of the patients with septic shock to whom it was administered

For a fuller discussion, read Is IV Vitamin Therapy Safe

Oral administration of glutathione alone is thought to be ineffective for altering glutathione levels due to hydrolysis during digestion and poor absorption

doi: 10.1186/s12879-018-3335-y