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Studies employing normal stromal fibroblasts subjected to 12 common chemotherapeutic drugs, including cisplatin, carboplatin, and paclitaxel, showed that cells maintained under such a regimen consume much more glucose and generate more lactate, which is then released through overexpressed proton-linked monocarboxylate transporter MCT4, leading to augmented acidification of extracellular environment [33]

J., Santostasi, G., Baron, K

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In addition, the physiological sensors recording the electrocardiogram (ECG) and the chest (thoracic) expansion/contraction at 256 Hz were used