These chemicals can mimic estrogen in the body, interfere with natural estrogen, or affect how the body makes and breaks down estrogen.9 Everyday estrogen disruptors and where they can be found include:10,11,12 Bisphenol A (BPA) : Found in plastic products, food cans, and dental sealants Phthalates : Used in plastics, personal care products, and food packaging Polychlorinated biphenyls (PCBs) : Industrial chemicals found in old electrical equipment and building materials Polybrominated diphenyl ethers (PBDEs) : Used as flame retardants in furniture, electronics, and textiles Pesticides : Including DDT, atrazine, and organophosphates Parabens : Used as preservatives in cosmetics and personal care products Per- and polyfluoroalkyl substances (PFAS) : Found in non-stick cookware, water-resistant clothing, and food packaging Triclosan : An antibacterial agent used in some soaps and personal care products Heavy metals : Such as lead, mercury, and cadmium Dioxins : Industrial byproducts that can contaminate food and the environment Alkylphenols : Used in detergents, pesticides, and personal care products Symptoms and Health Risks Associated with High Estrogen Common symptoms you might experience if you're young and your estrogen levels are too high, especially if combined with low progesterone, include: Irregular periods Heavy bleeding Bloating and weight gain, especially around the waist and hips Breast tenderness or swelling Mood swings and irritability Headaches Feeling tired all the time Less interest in sex Lumpy or painful breasts Worsening of PMS symptoms Hair loss Trouble sleeping Feeling agitated or blue Some of the health risks associated with excessive estrogens, both natural and synthetic, include:13 Uterine fibroids Thyroid suppression Ovarian cysts Autoimmune issues Infertility Remember, if you're experiencing these signs and symptoms, it's important to talk to a doctor
Figure 1 The decreased levels of insulin, and increased levels of glucagon activates the hormone-sensitive lipase (HSL) involved in lipolysis and secretes non-esterified fatty acids (NEFAs) from fat cells ( -oxidation takes place in the mitochondria creating acetyl-CoA
gingivalis was mainly dependent on myeloid differentiation primary response 88 (MyD88), which requires synergistic TLR2 and TLR4 signaling
IGF-I secretion is shown to reduce with aging (Figure 1) and that thereby reduces GH pulse amplitude and decreased overall GH production even though they maintained similar pulse frequency (9)
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Follow-up Repeat metabolic markers after 4-12 weeks, with closer review during dose escalation or major appetite changes
