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However, this difference was not statistically significant (p=0.270)

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Additional preclinical studies looking at the safety and efficacy of the combined treatment with pramlintide/phentermine and pramlintide/sibutramine was evaluated in a randomized placebo-controlled study with 244 obese or overweight nondiabetic subjects (203)

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Leung S, Mattman A, Snyder F, Kassam R, Meneilly G, Nexo E