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Transl Psychiatry 8 , 91 (2018)

D., Rother, J

doi: 10.1016/j.trci.2018.06.014 163 KleinbergerG.YamanishiY.Surez-CalvetM.CzirrE.LohmannE.CuyversE.et al

Iqirvo is intended to be used in combination with ursodeoxycholic acid (UDCA) in adult patients who have an inadequate response to UDCA, or as monotherapy in patients unable to tolerate UDCA

At the cellular interface, dermal fibroblasts regulate spreading, migration, and extracellular matrix (ECM) turnover through integrin-dependent adhesion signaling (e.g., FAK/ERK pathways), which is central to fibroblastECM homeostasis [48]