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Spirochetes found in synovial microangiopathic lesions

Once in the central nervous system, they act as potent neuroprotectants by inhibiting microglial over-activation, mitigating neuroinflammation via the TLR4/NF-B and NLRP3 pyroptosis pathways, and simultaneously upregulating tight junction proteins (e.g., Claudin-5, ZO-1) to restore or even enhance BBB integrity (Yue et al., 2021

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Homozygous loss-of-function mutations in the SLC2A9 (encoding the transporter protein GLUT9) and SLC22A12 (encoding the transporter protein URAT1) genes lead to hereditary renal hypouricemia type 1 and 2, respectively [21]

5-Amino-1MQ vs AOD-9604: Which Peptide Works Better