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Taken together, there is no doubt that measurement of endothelial function provides substantial prognostic information about future cardiovascular events in atherosclerotic disease and hypertension, whereas its role in primary prevention and whether the introduction of novel methods to assess endothelial function will further increase its prognostic potential 52 remains to be established

Sensitivity analysis: Model selection Global sensitivity analysis (GSA) was conducted using the classical Sobol method

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Although this novel approach will require further validation and exploration in clinical trials, it holds promise for improving the management of APAP-induced liver injury (Fig