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Nat Rev Mol Cell Biol 20:590607

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Data availability Bulk RNA sequencing data are available at the European GenomePhenome Archive under code EGAD50000001606

Its a gray area, but many clinics will screen for G6PD deficiency and advise against glutathione drips if positive, just out of precaution

Further support for a direct contribution of glutamate in the disease process came from blocking studies, applying Memantine, an N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor antagonist

The combination of ursolic acid and sorafenib inhibits SLC7A11 and reduces GSH synthesis, while significantly increasing lipid peroxidation levels, inducing ferroptosis in cells, and reversing drug resistance in liver cancer cells, thereby exhibiting significant antitumor activity and providing a new therapeutic strategy for tumor treatment