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van Diepeningen et al., 1997

In vivo, the aqueous methanol extract healed 40% of the mice and reduced the average tumor size by 39.29%

ALDH1A3 expression was confirmed at the protein level, and inhibition of ALDH1A3 expression using specific siRNAs significantly reduced ALDH activity and cell proliferation ( 2.4 ALDH1 in lipid peroxidation and ferroptosis Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death, characterized primarily by lipid peroxidation resulting from the excessive accumulation of intracellular lipid reactive oxygen species (ROS) (Figure 1E)

Cancer Manag Res 11 , 55015511 (2019)

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Quercetin was demonstrated to inhibit ferroptosis and improve joint cartilage destruction and degradation, delaying OA progression, by activating the AMP-activated protein kinase (AMPK)/Nrf2/GPX4 signaling pathway (Dong et al., 2025)