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PD The degeneration of dopaminergic neurons in PD is fueled by iron overload, mitochondrial dysfunction and oxidative stress, all of which are tightly linked to ferroptosis

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Transmitted primarily through saliva (the kissing disease), but also through blood and organ transplants

J Mol Neurosci 20(2):17388 Kovaleva V, Shpironok O, Yu L, Ivanova L, Fudo S, Happonen L, Toots U, Ustav M, Kajander T, Karelson M, Saarma M (2024) CDNF rescues human iPSCs-derived dopamine neurons through direct binding to unfolded protein response sensors PERK and IRE1

Also, Nishioku et al

One trial showed amateur runners taking 1,000mg NMN daily improved their aerobic capacity compared to placebo [3]