Interestingly, our study uncovered a novel function of miR-214 as a regulator of ferroptosis-driver genes ACSL4 , SLC38A1 , and PRKAA2
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The neuroprotective action of IHT might be associated with generation of reactive oxygen species which in turn activate an extensive defense program, including nuclear factor erythroid 2-related factor 2 (Nrf2)a transcriptional factor regulating expression of genes encoding numerous phase II defense enzymes that collectively afford powerful antioxidant and anti-inflammatory cytoprotection (Dringen et al., 2015)
Temozolomide (TMZ) promotes ferroptosis by upregulating DMT1 (205)
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