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CD4 + CD25 + FOXP3+) normally suppress autoreactive lymphocytes, but in HT, both their number and suppressive function are reduced, correlating with disease severity (Chen et al., 2023)

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Fermented foods are defined as foods made through desired microbial growth and enzymatic conversions of food components by The International Scientific Association of Probiotics and Prebiotics (ISAPP)

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Such next-generation agents are now in clinical trials for synucleinopathies (multiple system atrophy and PD), reflecting a promising direction for iron-targeted therapy