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In patients with reduced renal clearance, excessive magnesium intake may contribute to clinically significant hypermagnesemia, with manifestations ranging from mild gastrointestinal or neuromuscular symptoms to hypotension, bradycardia, respiratory depression, and cardiopulmonary arrest at higher serum magnesium levels, as summarized in Table 4

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Lactobacillus acidophilus and propionate attenuate Sjgren's syndrome by modulating the STIM1-STING signaling pathway