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Larazotide works complementarily by binding claudin receptors to restore the tight-junction barriers that, when compromised, allow bacterial endotoxins from periodontal pathogens to penetrate systemic circulation

For example: A brain condition called hepatic encephalopathy, which results from high levels of ammonia in the blood, can cause hand flapping tremors and changes in mental state much like uremia

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4.5 The gut microbiota-ferroptosis axis hypothesis in OA pathogenesis Elaborating on the above research evidence and theoretical conclusions, we postulate this gut microbiota-ferroptosis axis hypothesis to indicate this relationship plays a role in and is a mechanism in the pathogenesis of OA

doi:10.3389/fneur.2015.00144 Ciorba A, Bianchini C, Scanelli G, Pala M, Zurlo A, Aimoni C

Pathophysiology and epidemiology of chronic mountain sickness