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Many known treatments only address the symptoms that present with PD and do not look to the cause

Glutathione levels tend to decline with age, and this decline has been associated with various age-related conditions, including neurodegenerative diseases, cardiovascular disease, and cancer

In healthy people, 90% or more of total glutathione should be GSH, and GSH:GSSG ratios of less than 9:1 indicate oxidative stress

The two domains linked via a tetra-peptide loop, in addition to a carbohydrate-binding pocket are located at the N -terminal domain

Teixeira FB, Leo LKR, Bittencourt LO, Arago WAB, Nascimento PC, Luz DA, Braga DV, da Silva MCF, Oliveira KRM, Herculano AM, Maia CSF, Lima RR (2019) Neurochemical dysfunction in motor cortex and hippocampus impairs the behavioral performance of rats chronically exposed to inorganic mercury

doi: 10.3389/fonc.2022.1054399, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 428