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Those with the enzyme deficiency require lifelong treatment with an agent that has the same reducing effect as the deficient enzyme

Limit of detection was 0.64 pg mL 1 for GSH and 4.59 pg mL 1 for GSSG

( R )-(+)-lipoic acid is enzymatically or chemically reduced to ( R )-(-)-dihydrolipoic acid whereas ( S )-(-)-lipoic acid is reduced to ( S )-(+)-dihydrolipoic acid

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