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One of the key reasons for introducing such modifications is to protect the single-stranded regions, particularly hairpin loops crucial for target interaction, from degradation by RNase A enzymes

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Obviously well have to watch for this in the phase 3 Eloralintide trials as well, but given its highly selective activity on Amylin receptors and lack of engagement on the calcitonin receptor, it may not develop into an issue at the doses Lilly is testing

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