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In a review from Chandra et al., the author suggests to stay in the target trough level, albeit risking over-immunosuppression, and only reduce Tac dose if nephrotoxicity is suspected (113)

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This study not only uncovers the central role of Chac2 in immunometabolism reprogramming for the first time, but also provides a new perspective for understanding how periodontal inflammation alters neutrophil functional states to influence systemic disease progression

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