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The integrated stress response: from mechanism to disease

116,126 Specifically, CCS-overexpressing SOD G93A mice exhibit significantly decreased COX activity when these mice reached the end stage of disease, whereas SOD G93A mice not overexpressing CCS had no apparent decrease in COX activity at the same stage, 126 supporting the hypothesis that overexpressing CCS increases the delivery of Cu to SOD1 while reducing the delivery of Cu to other enzymes (e.g., mitochondrial cytochrome c oxidase), thus leading to additional toxic effects

But I told you, what I told you is the truth

An attractor hypothesis of obsessive-compulsive disorder

It is best consumed fresh and in moderate quantities

Cheilitis granulomatosa (of Miescher) , persistent painless lip swelling alone, considered by many to be a form of orofacial granulomatosis confined to the lip