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This defense mechanism comprises three tiers: (1) preventive antioxidants that suppress the formation of free radicals [56], (2) radical-scavenging antioxidants that rapidly eliminate generated free radicals [54], and (3) reparative/generative mechanism for repairing and regenerating DNA, lipids, and proteins damaged by free radicals

A typical brewed green tea beverage, consisting of 25 g tea leaves in 250 ml of hot water, contains 2050 mg caffeine (Reference Balentine, Wiseman and Bouwens49,Reference Sang, Lambert and Ho50) , compared with 235 mg caffeine in 12 fluid oz

However, it is always best to consult with a healthcare provider before starting any new supplement regimen

Acknowledgements This work was created as part of NCCR Catalysis, a National Centre of Competence in Research funded by the Swiss National Science Foundation (grant number 180544 to R.M.B) and by AEI (Spain) (grant number RTI2018-099592-B-C22 to G.J.-O)