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Excess intracellular iron catalyzes Fenton reactions, generating reactive oxygen species (ROS) that oxidize polyunsaturated fatty acids (PUFAs) in membranes [88], resulting in membrane rupture and cell death (Fig

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Clin Cancer Res (2011) 17(18):600011

Antagonists of G-protein-coupled receptor family C group 6 subtype A (GPRC6A) abolished the additive effect of ornithine on preference for MSG solutions in both behavioral and electrophysiological experiments, suggesting that ornithine is a kokumi substance that binds to another possible kokumi receptor, GPRC6A

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(35) found no differences in blood pressure between the probiotic group and the placebo group and at any time point at baseline