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FIGURE 1 Measure of skin lesion, dermatitis score, and ear thickness The ear thickness was measured the day after each DNCB application by using an electronic vernier caliper (Decimal Caliper, Asa Dental spa, Lucca, Italy) and a digital camera to record clinical symptoms

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A combined topical + oral study showed better effect than monotherapy

No particular funding from a public, private, or nonprofit organization was received for this research

The database of the Ribosomal database project (RDP release 16) was used for classification

This systems-level strategy facilitates the identification of biomarkers and therapeutic targets that may be missed by single-omics analyses, offering novel insights into functional heterogeneity and opportunities for precision interventions