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For further clinical progress, some key aspects should be considered for optimal clinical translation, such as: (1) Discerning if the combination or coupling of therapeutic agents, imaging agents, and carriers or ligands will change the pharmacokinetics and biodistribution of the carried drugs, and if it will cause new side effects

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Therefore, studying the mutant pir1 is significant for elucidating lesion mimic genes and the interdependent regulatory mechanisms between closely associated functional genes

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113,114 In MASLD and MASH, E3 ligases play dual roles, with both protective and pathological implications

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