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In line with this, scientists at UCB demonstrated that the Fab of the anti-FcRn mAb rozanolixizumab could be expressed in a range of non-classical Ab formats with only one Fab, as opposed to the two found in classical bivalent IgGs, and retain the ability to shorten the plasma half-life of exogenously administered human IgG in human FcRn transgenic mice [124]

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Imaging and analysis For immunohistochemical outcome measures, the rostral and caudal medial corpus callosum were visualised using a Nikon A1 confocal microscope (Nikon Corporation, Australia, Coherent Scientific), and a series of 13 images were taken at 0.5 m increments along the z-axis at a magnification of 20 and a numerical aperture of 0.75

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