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To this end, SIRT4 activation upon DDR has been shown to inhibit glutamine consumption in HepG2, HeLa, HEK293T cells, and in lung tissue (58)

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Ortiz-Munoz G, Houard X, Martin-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O

SanMiguel N, Lopez-Cruz L, Muller CE, Salamone JD, Correa M

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