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Two complementary lineagessystem Xc inhibitors and GPX4-directed agentsoffer improvements in potency, stability, or solubility, yet translation is constrained by on-target depletion of cystine and glutathione in normal tissues and by off-target perturbations, including mitochondrial channel engagement and p53 pathway modulation, which collectively narrow the therapeutic index

10.1016/j.jnutbio.2019.05.002 233 ZhangR.ZhangH.ZhuW.PardeeA

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