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However, mechanisms underlying regulation of degradation are complex, and particularly, there are many kinds of endogenous proteases and their regulatory mechanisms are more complex and play a crucial role in the process of RTPs degradation

Glutathione (GSH) represents a well-known major physiological mechanism of response to oxidative stress, interacting with SOD, as shown in Figure 1 (De-Haan et al., 1996

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Tin Wui Wong Yang Yang, Chaoyong Tian, Xiaogang An, Bei Fan, Dingjun Zha Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xian, 710032, Peoples Republic of China Correspondence: Dingjun Zha, Email [email protected] Abstract: Globally, more than 1.6 billion individuals are affected by hearing loss