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Antibodies of the invention can be used to assay protein levels in a biological sample using classical immunohistological methods known to those of skill in the art (e.g., see Jalkanen, et al., J

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In the absence of activating stimuli, the stability of Hif1a is regulated by hydroxylase domain proteins (PHDs) and the von Hippel-Lindau tumor suppressor protein (VHL)

58,59 Moreover, in 1971, Corey and Skoulos successfully synthesized prostaglandins, and during the 1970s, Brown and Goldstein discovered the low-density lipoprotein receptor pathway, which not only provides cells with the cholesterol necessary for constructing cell membranes and other biomolecules but also helps to maintain cholesterol homeostasis in the plasma