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Caspase-dependent protein degradation is also attenuated by IGF/PI3K/Akt signaling, whereas evidence for an effect on calpain-dependent protein degradation is inconclusive

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In contrast, oxidized forms of sulfur-containing amino acids (e.g., methionine sulfoxide, cystine), as well as of arginine, increased (Figure 4A)

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In MASLD, elevated SAA levels may reflect hepatic inflammation and the resulting tissue damage associated with this inflammatory process [209]