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(2) Targeting signaling pathways to inhibit the formation of DTP cells

doi: 10.1056/NEJMra1213566 146 SaitoSNishikawaKMoriiTNaritaNEnomotoMIchijoM

doi: 10.1038/nature13241 228 NikulinJ.PanznerU.FroschM.Schubert-UnkmeirA

When used over time, arbutin may also be more effective than other natural ingredients, such as Kojic acid

Unfortunately, MTX cytotoxicity is not limited to cancer cells but extends to affect non-cancer cells of vital organs such as intestinal mucosa (Tang et al