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Description

After crossing the BBB, lead accumulates in astroglial cells (containing lead binding proteins)

Aberrant activation of c-MET can lead to both tumors growth and metastatic progression of cancer cells

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This disparity is hypothesized to arise from differences in estrogen-mediated neuroprotection, lifestyle factors, and occupational exposure to neurotoxins (Ben-Shlomo et al., 2024) (Figure 2)