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Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

provided PCs to T2D mice (75, 150, and 300 mg/kg) via continuous gavage for 4 weeks, documenting improvements in intestinal barrier integrity by restoring morphology and raising the expression of tight junction proteins, including Zonula occludens-1 (ZO-1), Claudin-1, and occludin

there are some scholarly articleso n this published in sweeden in late 90s that confirmed this existence in mercury exposed individuals

Based on the UK Biobank data, genetic prediction of vitamin B12 concentrations showed no association with liver enzymes in the main analysis (IVW-multiplicative random effects)

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