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Iruarrizaga-Lejarreta M, Varela-Rey M, Fernandez-Ramos D, Martinez-Arranz I, Delgado TC, Simon J, Juan VG, delaCruz-Villar L, Azkargorta M, Lavin JL, Mayo R, Van Liempd SM, Aurrekoetxea I, Buque X, Cave DD, Pena A, Rodriguez-Cuesta J, Aransay AM, Elortza F, Falcon-Perez JM, Aspichueta P, Hayardeny L, Noureddin M, Sanyal AJ, Alonso C, Anguita J, Martinez-Chantar ML, Lu SC, Mato JM

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.De Gregori I., Fuentes E., Rojas M., Pinochet H., Potin-Gautier M

These free radicals are the agents of aging, and too many of them can leave the door open for aggressive diseases such as cancer

Additionally, drug associated metabolic effects may be due to factors other than weight gain as studies in preclinical models using clinically relevant doses of AA medications indicate that insulin resistance, immune dysfunction and NAFLD can occur prior to drug associated weight gain (Houseknecht et al., 2007

Curr Gastroenterol Rep