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38 Moreover, p53 loss in our cellular model leads to the upregulation of xCT, promoting cystine import and GSH synthesis to shield cells from ferroptotic cell death

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It may possibly reflect differences in the occupancy of the hydrophobic pocket in VP1, or at another site affecting stability, since the ternary complexes of PV3-SC8 GPP3+GSH and PV3-SC8 pleconaril+GSH demonstrate that the bound factors could act additively or synergistically

doi: 10.1016/S0092-8674(00)80611-X

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