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While considerable efforts have been directed toward understanding the peripheral mechanisms of CIPN, emerging evidence indicates that CIPN-causing agents also induce changes in CNS neurons, leading to the development of central sensitization (Figure 2E)

Hum Ecol Risk Assess Int J

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if PD dysbiosis includes SFB or others with similar effects, it could promote CNS inflammation that accelerates neurodegeneration [162]

Hintze K

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