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Au NPs also decreased GEM resistance in cancer (420)

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10.3389/fbioe.2022.866195 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang J., Zhu Q., Cao D., Peng Q., Zhang X., Li C., et al

In the case of intrinsic apoptosis, which is mainly associated with mitochondrial dysfunction or ER stress, ROS can activate the cell cycle regulators p53 and JNK, which induce pro-apoptotic Bcl-2 family proteins such as Bak and Baxantagonists to anti-apoptotic proteins Bcl-xL and Bcl-2 in the outer mitochondrial membrane (OMM)eventually causing mitochondrial outer membrane permeabilization and subsequent apoptosis [136, 137]