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Serum ACE1 and ACE2 levels and the ACE1/ACE2 ratio are associated with several comorbidities that can worsen COVID-19 severity, including hypertension, type II diabetes, obesity and cardiovascular disease, and in those who smoke 14

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11 Female Hormonal (Menstrual) Cycle Female fertility is controlled by cyclic hormone signals from the hypothalamus and pituitary gland via the hypothalamic-pituitary-ovarian (HPO) axis