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Figure 13 summarizes key intracellular glutathione (GSH) sensing strategies, encompassing fluorescent probes that detect reduced GSH through light emission, enzymatic biosensors that generate electrical signals via GSHNAD(P)H redox cycling, quantum nanoprobes that enable high-resolution fluorescence shifts, and nanomaterial-based sensors that act as GSH-responsive reporters for gene editing and signal amplification

Regulation and removal of hydrogen peroxide prevents the formation of the highly reactive and damaging hydroxyl radical, which can be formed by reaction of hydrogen peroxide with Fe 2+ (Fenton reaction)

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( h ) The levels of mRNAs encoding Myc and Rnd1 exhibit an inverse correlation in 3 breast cancer DNA microarray datasets

Indeed, the ability to scavenge host produced ROS is a virulence factor in many phytopathogenic fungi, and disruption of oxidative stress enzymes, such as superoxide dismutase (SOD), can result in lower virulence (53)

Exogenous supplementation of Monounsaturated Fatty Acid(MUFA), stearoyl-CoA desaturase (SCD1)-mediated cellular MUFA production, and Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3)-dependent MUFA membrane enrichment have been reported to reduce the propensity of cells to die by ferroptosis (37).The main byproduct of lipid peroxidation is lipid hydroperoxides