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In the first two studies, changes in redox and methylation metabolism were reported but because the studies were open-label the changes in these biomarkers were not compared to a placebo group

ChenVMoncalvoMTringaliDTagliafierroLShriskandaAIlichEet al

Glucuronic acid conjugation, sulfate conjugation, amino acid conjugation, glutathione conjugation, acetylation, methylation are different types of phase II metabolic reactions

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Loss of PMK-1 (transcription factor of p38 MAPK) compromises the extended lifespan of daf-2(e1370) (insulin/insulin-like growth factor (IGF) receptor longevity mutant) 45