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It is linked to histone modifications that regulate inflammatory pathways, with Nox5, a newly identified NADPH oxidase, serving a key role by generating superoxide, leading to oxidative stress and promoting As development

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Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: randomized, placebo-controlled, double-blind split-mouth clinical trial

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Experimental and clinical data also demonstrate transient immunosuppression (reductions in immune cell numbers up to 48 h, cytokine changes beyond 96 h), which is biologically consistent with the infection signals discussed below