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However, when looking at the kinetics of HLA- and non-HLA-antibody appearance, GSTT1Ab onset was observed within the first post-transplant year, and often preceded HLA-DSAs, likely as a consequence of cryptic antigen release secondary to ischemia reperfusion and/or inflammatory injury

Conclusion: These results demonstrate Primes LNP-RNA Prime Editors are efficiently and safely delivered to primate liver, resulting in durable, efficient and precise correction of two prevalent mutations and reversing hypoglycemia and growth retardation in humanized mice

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Functional interactions and proteinprotein interactions for high-confidence candidate regulators were identified using the GO enrichment analysis and STRING interaction network database