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While it is located in several tissues such as fat and muscle, I want to pay attention to how NNMT affects your body weight: [NNMT is] a cytosolic enzyme that plays a role in cellular metabolism and energy homeostasis

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[DOI] [PubMed] [Google Scholar] 26.Shigemura Y, Iwai K, Morimatsu F, Iwamoto T, Mori T, Oda C, et al

Following xenobiotic exposure, enzyme induction and its associated hepatocellular hypertrophy are not usually immediately apparent, with a maximal response occurring a few days to a week or more after exposure, since the enzyme inducer must first reach steady state, and new drug-metabolizing enzymes need to be synthesized

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10.1111/j.1365-2125.2006.02690.x Summary Keywords single nucleotide polymorphism, adverse effect, methotrexate, azathioprine, cyclophosphamide, mycophenolate mofetil Citation Hamdani S, Hamijoyo L, Amalia R and Barliana MI (2025) Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review