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REFERENCES [i] Kontos AP et al

D.NieS.AngC

Intestinal oxidative damage in inflammatory bowel disease: semiquantification, localization, and association with mucosal antioxidants

It downregulates nNOS mRNA expression confirmed by real-time polymerase chain reaction (RT-PCR)

Stress, pollution, and a poor diet pull it down further

In the nucleus, Nrf2 interacts with small Maf proteins (sMAF) and binds to antioxidant response elements (ARE), promoting the transcription of downstream antioxidant genes (Yan et al., 2023)